Research Diets饲料/Research Diets高脂饲料/Research Diets动物饲料13611631389上海睿安生物

    动物饲料(Research Diets是生产动物实验用高脂肪饲料的先驱，可配制高达 60 kcal%的高脂肪饲料，成份內含各式脂肪及碳水化合物，ResearchDiet长期陪伴实验室科研人员，以配制研究需要的饲料配方，可用于诱发肥胖病及糖尿病的特殊饲料如D12450B、D12451及 D12492。)  全面、便捷、快速、保障、您的生命研究订购助手，上海市内现货2天内到达实验室，期货稳定，无现货时一般3周到达上海。

    配方成分：
    Casein lactic酪蛋白、L-Cystine胱氨、CornStarch玉米淀粉、Maltodextrin麦芽糊精、Sucrose蔗糖、Cellulose BW200纤维素、SoybeanOil豆油、Lard猪油、Mineral Mix S10026*复合矿物质、DiCalcium Phosphate 磷酸氢钙、CalciumCarbonate碳酸钙、Potassium Citrate(1 H2O)柠檬酸钾、Vitamin Mix V10001*复合维生素、Choline Bitartrate酒石酸氢胆碱。
Research Diets D12492

Description:Rodent Diet with 60% kcal% fat.

Used in Research:Obesity, Diabetes

Packaging:Product is packed in 12.5 kg box.Each box is identified with the
product name, description, lot number and expiration date.

Lead Time:IN-STOCK. Ready for next day shipment.

Gamma-Irradiation:Yes. Add 10 days to delivery time.

Form:Pellet, Powder, Liquid

Shelf Life:Most diets require storage in a cool dry environment. Stored correctly they should last 3-6 months. Because of the high fat content is best if kept frozen.

Control Diets:D12450B

D12450B, D12451, D12492 The "Original High Fat Diets"  REFERENCES
1. Van Heek M, et al. Diet-induced Obese Mice Develop Peripheral, but not Central Resistance to Leptin.J. Clin. Invest. 1997; 99:385-390.
2. Taheri S, et al. Distribution and quantification of immunoreactive orexin A in rat tissues.FEBS Lett. 1999 Aug 20; 457(1):157-61.
3. Nonogaki K, et al. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nature Medicine 1998; 4:1152-1156.
4. El-Haschimi K, et al. Two defects contribute to hypothalamic leptin esistance in mice with diet-induced obesity. J.Clin.Invest. 2000; 105:1827-1832.
5. Bush EN, et al.(Metabolic Disease Research, Abbott Laboratories) Adiposity, Leptin Resistance, Hyperrphagia, Hyperglycemia, Glucose Intolerance and Insulin Resistance in C57BL/6J Mice Fed High Fat Diets.Endocrine SocietyAnnual Meeting 2001, Poster Session.
6. Shapiro ME, et al. (Metabolic Disease Research, Abbott Laboratories) Effects of Treatment of C57BL/6j Mice Fed High vs. Low Fat Diets with Metformin or Rosiglitazone on Adiposity, Food Intake, Hyperglycemia and Insulin Resistance .Endocrine Society Annual Meeting 2001, Poster Session.
7. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS. A Transgenic Model of Visceral Obesity and the Metabolic Syndrome. Science. 2001;294:2166-2170.
8. Razani B, Combs TP, Wang XB, Frank PG, Park DS, Russell RG, Li M, Tang B, Jelicks LA,Scherer PE, Lisanti MP. Caveolin-1 deficient mice are lean, resistant to diet-induced obesity,and show hyper-triglyceridemia with adipocyte abnormalities. J. Biol. Chem. 2001; (in press).
9. Valet P, Grujic D, Wade J, Ito M, Zingaretti MC, Soloveva V, Ross SR, Graves RA, Cinti S,Lafontan M, and Lowell BB. Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity.
J.Biol.Chem. 275: 34797-34802, 2000.
10. Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J,Mootha V, Cortright R, Muoio DM, and Lowell BB. Energy metabolism in uncoupling protein 3 gene knockout mice. J.Biol.Chem. 275: 16258-16266, 2000.
11. Ziotopoulou M, Mantzoros CS, Hileman SM, & Flier JS. Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice. Am. J.Physiol. Endocrinol. Metab. 279:E383-E845, 2000.
12. Scrocchi LA & Drucker DJ. Effects of Aging and a High Fat Diet on Body Weight and Glucose Tolerance in Glucagon-Like Peptide-1 Receptor -/- Mice. Endocrinology 139:3127-3132, 1998.
13. Ghibaudi L, Cook J, Farley C, Van Heek M, & Hwa J.Fat Intake Affects Adiposity,Comorbidity Factors, and Energy Metabolism of Sprague-Dawley Rats. Obes. Res. 10:956-963. 2002
14. Dube MG, Beretta E, Dhillon H, Ueno N, Kalra PS & Kalra SP. Central Leptin Gene Therapy Blocks High-Fat Diet-Induced Weight Gain, Hyperleptinemeia, and Hyperinsulinemia. Diabetes 51:1729-1736, 2001.
15. Tang H, Vasselli JR, Wu EX, Boozer CN, & Gallagher D. High-Resolution Magnetic Resonance Imaging Tracks Changes in Organ and Tissue Mass in Obese and Aging Rats. Am J Physiol (Regulatory Integrative Comp Physiol) 282:R890-R899, 2002.
16. Bowen H, Mitchell TD, & Harris RBS (Dept. of Foods and Nutr, U of Georgia). Method of Leptin Dosing, Strain, and Group Housing Influence Leptin Sensitivity in High-Fet-Fed Weanling Mice. AJP-Regul Integr Comp Physiol 284:R87-R100, 2003.
17. Harris RBS, Mitchell TD, & Hebert S (Pennington Biomedical Research Center, Baton Rouge, LA). Leptin-Induced Changes in Body Composition in High Fat-Fed Mice. AJPRegul Integr Comp Physiol 284:R87-R100, 2003.
18. Anini, Y. and Brubaker, P. L. Role of Leptin in the Regulation of Glucagon-Like Peptide-1 Secretion. Diabetes 52:252-259, 2003.
19. Bluher, S., Responsiveness to Peripherally Administered Melanocortins in Lean and Obese Mice. Diabetes 53:82-90, 2004.
20. Brunengraber, D. Z., et al. Influence of diet on the modeling of adipose tissue triglycerides during growth. Am J Physiol Endocrinol Metab 285: E917-E925, 2003.
21. Challis, B. G., et al. Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY3-36. PNAS 101: 13: 4695-4700, 2004.
22. Cohen, A. W., B. Razani, X. B. Wang, T. P. Combs, T. M. Williams, P. E. Scherer, and M. P.Lisanti. Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue. Am J Physiol Cell Physiol 285: C222-C235, 2003.
23. Combs, T. P., et al. A Transgenic Mouse with a Deletion in the Collagenous Domain of Adiponectin Displays Elevated Circulating Adiponectin and Improved Insulin Sensitivity.Endocrinology 145:367-383, 2004.
24. Conarello, S. L., et al. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. PNAS, 100:11: 6825-6830, 2003.
25. Dhar, M. S., et al. Mice Heterozygous for Atp10c, a Putative Amphipath, Represent a Novel Model of Obesity and Type 2 Diabetes. J. Nutr. 134: 799-805, 2004.
26. El-Haschimi, K., S. D. Dufresne, M. F. Hirshman, J. S. Flier, L. J. Goodyear, and C.Bjørbæk. Insulin Resistance and Lipodystrophy in Mice Lacking Ribosomal S6 Kinase 2.Diabetes 52:1340-1346, 2003.
27. Felipe, F., M. L. Bonet, J. Ribot, and A. Palou. Modulation of Resistin Expression by Retinoic Acid and Vitamin A Status. Diabetes 53:882-889, 2004.
28. Felipe, F., M.L. Bonet, J. Ribot and A. Palou. Up-regulation of muscle uncoupling protein 3 gene expression in mice following high fat diet, dietary vitamin A supplementation and acute retinoic acid-treatment. International Journal of Obesity 27: 60-69, 2003.
29. Fu, J., et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR. Nature 425:90-93, 2003.
30. Gavrilova, O., et al. Liver Peroxisome Proliferator-activated Receptor Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass. The Journal of Biological Chemistry 278:36:34268-34276, 2003.
31. Haluzík, M., O. Gavrilova and D. LeRoith. Peroxisome Proliferator-Activated Receptor-Deficiency Does Not Alter Insulin Sensitivity in Mice Maintained on Regular or High-Fat Diet: Hyperinsulinemic-Euglycemic Clamp Studies. Endocrinology 145:1662-1667, 2004.
32. Hancock, A.A. et al. Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. European Journal of Pharmacology 487:183-197, 2004.
33. Hennige, A. M., et al. Upregulation of insulin receptor substrate-2 in pancreatic b cells prevents diabetes. J. Clin. Invest. 112:1521-1532, 2003.34.
34. Hildebrandt, A. L., D. M. Kelly-Sullivan, S. C. Black. Validation of a high-resolution X-ray computed tomography system to measure murine adipose tissue depot mass in situ and longitudinally. Journal of Pharmacological and Toxicological Methods 47: 99- 106, 2002.
35. Hileman, S. M., D.D. Pierroz, H. Masuzaki, C. Bjørbæk, K. El-Haschimi, W. A. Banks,and J. S. Flier. Characterizaton of Short Isoforms of the Leptin Receptor in Rat CerebralMicrovessels and of Brain Uptake of Leptin in Mouse Models of Obesity. Endocrinology 143:775-783, 2002.
36. Ishii, M., H. Fei, and J. M. Friedman. Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. PNAS 100:18:10540-10545, 2003.
37. Joseph, J. W., V. Koshkin, C-Y Zhang, J. Wang, B. B. Lowell, C. B. Chan, and M.B.Wheeler. Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet. Diabetes 51:3211-3219, 2002.
38. Kim, S., et al. Effects of High-Fat, Angiotensinogen (agt) Gene Inactivation, and Targeted Expression to Adipose Tissue on Lipid Metabolism and Renal Gene Expression. Horm Metab Res 34:721-725, 2002.
39. Kumar, M. V., T. Shimokawa, T. R. Nagy, and M. D. Lane. Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. PNAS 99:4: 1921-1925, 2002.
40. Lambert, P. D., et al. Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. PNAS 98:8: 4652-4657, 2001.
41. Le Laya, S., et al. Decreased Resistin Expression in Mice with Different Sensitivities to a High-Fat Diet. Biochemical and Biophysical Research Communications 289:2:564-567,2001.
42. Li, J., K. Takaishi, W. Cook, S. K. McCorkle, and R. H. Unger. Insig-1 ''brakes'' lipogenesis in adipocytes and inhibits differentiation of preadipocytes. PNAS 100:16:9476-9481, 2003.
43. Ludwig, D. S., et al. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J. Clin. Invest. 107:379-386, 2001.
44. Moon, Y. S., et al. Mice Lacking Paternally Expressed Pref-1/Dlk1 Display Growth Retardation and Accelerated Adiposity. Molecular And Cellular Biology 22:15: 5585-5592,2002.
45. Murray, I., A. D. Sniderman, P. J. Havel, and K. Cianflonei. Acylation Stimulating Protein (ASP) Deficiency Alters Postprandial and Adipose Tissue Metabolism in Male Mice. TheJournal Of Biological Chemistry 274:51:36219-36225, 1999.
46. Phan,L. K., F. Lin, C. A. LeDuc, W. K. Chung, and R. L. Leibel. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.J. Clin. Invest. 110:1449-1459, 2002.
47. Pierroz, D. D., M. Ziotopoulou, L. Ungsunan, S. Moschos, J. S. Flier, and C. S. Mantzoros.Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity. Diabetes 51:1337-1345, 2002.
48. Rosenfeld, C. S., K. M. Grimm, K. A. Livingston, A. M. Brokman, W. E. Lamberson, and R. M. Roberts. Striking variation in the sex ratio of pups born to mice according to whether maternal diet is high in fat or carbohydrate. PNAS 100:8:4628-4632, 2003.
49. Chirala, S. S., et al. Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero. PNAS 100:11:6358-6363,2003.
50. Takahashi, N., et al. Divergent Effects of Leptin in Mice Susceptible or Resistant to Obesity.Horm Metab Res 34:691-697, 2002.
51. Thupari, J. N., L. E. Landree, G. V. Ronnett, and F. P. Kuhajda. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. PNAS 99:14:9498-9502,2002.
52. Tortoriello, D. V., J. Mcminn, and S. C. Chua. Dietary-Induced Obesity and Hypothalamic Infertility in Female DBA/2J Mice. Endocrinology 145: 1238-1247, 2004.
53. Weisberg, S. P., et al. Obesity is associated with macrophage accumulation in adipose tissue.J. Clin. Invest. 112:1796-1808, 2003.
54. Xu, H. et al. Chronic inflammation in fat plays a crucial role in the development of obesityrelated insulin resistance. J. Clin. Invest. 112:1821-1830, 2003.
55. Yamashita, T., et al. Enhanced insulin sensitivity in mice lacking ganglioside GM3. PNAS 100:6:3445-3449, 2003.
56. Bagnasco, M., M. G. Dube, A. Katz, P. S. Kalra, and S. P. Kalra. Leptin Expression In Hypothalamic Pvn Reverses Dietary Obesity And Hyperinsulinemia But Stimulates Ghrelin.Obes Res. 11:1463-1470, 2003.
57. Borowsky, B., et al. Antidepressant, anxiolytic and anorectic effects of a melaninconcentrating hormone-1 receptor antagonist. Nature Medicine 8:8:825-830, 2002.
58. Chan, C. B., et al. Increased Uncoupling Protein-2 Levels in b-cells Are Associated With Impaired Glucose-Stimulated Insulin Secretion. Diabetes 50:1302-1310, 2001.
59. Chen, L. and B. L. G. Nyomba. Glucose Intolerance and Resistin Expression in Rat Offspring Exposed to Ethanol in Utero: Modulation by Postnatal High-Fat Diet.Endocrinology 144:500-508, 2003.
60. Farley, C., J. A. Cook, B. D. Spar, T. M. Austin, and T. J. Kowalski. Meal Pattern Analysis Of Diet-Induced Obesity In Susceptible And Resistant Rats. Obes Res. 11:845-851, 2003.
61. Gao, J., L. Ghibaudi, M. Van Heek, J. J. Hwa. Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet. Brain Research 936:87-90, 2002.
62. Ogilvie, K. M., R. Saladin, T. R. Nagy, M. S. Urcan, R. A. Heyman, and M. D. Leibowitz.Activation of the Retinoid X Receptor Suppresses Appetite in the Rat.Endocrinology 145:565-573, 2004.
63. Shklyaev, S., et al. Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. PNAS 100:24:14217-14222, 2003.
64. Hildebrandt, A. L., D. M. Kelly-Sullivan, S. C. Black. Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice. European Journal of Pharmacology 462:125-132, 2003.